Immunology Essay Exam Questions And Answers


  • For sample exam questions, see case outside D Review self-quiz 8. READ again. Study exercises and questions: 1. Summarize the immune response to tumor cells. Which is more effective, a humoral response or a cell mediated response? Support your...
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  • Give one example each of primary immunodeficiencies involving T cells, B cells, phagocytes, and C'. Describe cause, symptoms, and prognosis or outcome. What understanding regarding immune function can be gained by studying immunodeficiency?...
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  • A third group were taught active coping skills and relaxation techniques. At the end of the study, it was found that the third group showed improved NK cell activity. The second group showed no change from that at the beginning of the study or from the control group. However, both the second and third groups reported subjectively feeling better about themselves and about things in general.
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  • The control group reported no change in attitude. Describe a probable mechanism for the effect seen in the third group. Include the source and mediators involved, as well as the target s for the mediators. Both the second and third groups reported improved outlook, yet only the third group improved their NK activity. What is a probable explanation for this difference? What would be another type of indicator system which could be used to study the effects of stress? How would you construct your study? Under normal circumstances, humans do not make antibodies to self-components, e. What are three possible explanations for this type of self-tolerance? Following a penetrating injury to one eye, a 30 year-old patient was found to have antibodies to retinal antigens. These antibodies were causing major complications in the healing of the eye.
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  • This patient had no prior history of autoimmune disease. Would antibodies to retinal antigens normally be found? Why not? Why did this patient develop antibodies to the retinal antigens? As a young physician interested in immunology, you have a brilliant idea. One common type of leukemia is a cancer of the lymphocyte. Why not irradiate these leukemia patients with a dose of X rays sufficient to destroy all their lymphocytes i.
    Link: https://ajp.psychiatryonline.org/doi/full/10.1176/appi.ajp.2013.13020178
  • The host's immune system is destroyed, hence the cancer should be cured. An older colleague finds your proposal highly amusing. Give two reasons why and discuss. Your colleague suggests that a better alternative would be to remove some of the patient's bone marrow before whole-body irradiation and treat the stem cells in vitro to remove the leukemic cells, and then return the bone marrow to the patient following the irradiation.
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  • Describe one way in which leukemia cells could be removed in vitro. What are the possible limitations of your method? Upon examining Z cells isolated from Horta, the cells were shown to be defense cells. It was found that they reproduced primarily in response to an autocrine signal. In other words, Z cells produced a stimulating factor and also expressed receptors for the stimulating factor. When cultured in vitro, they only produced the stimulating factor if physically disturbed or if toxins were added. Describe the advantages of this reproductive system for Z cells in vivo. What are some of the possible disadvantages? If a kidney patient could choose between an HLA haplo-identical sibling only one HLA haplotype matched or a parent as a possible donor, who will you recommend? An 81 year old woman was admitted to the hospital with wheezing and difficulty breathing.
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  • The attending physician noted that the symptoms were similar to asthma, and prescribed corticosteroid treatment. There was some initial improvement; but after five days, she was having increased difficulty.
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  • Dryness from hormone replacement E. An 8-year-old male has asthma symptoms about three times per month requiring the use of an albuterol inhaler, despite adequate inhaled steroid treatment. These episodes typically occur at night. The child is not allergic to his guinea pig or dust mites, and there is no smoking in the home. He has no problems with exercise and rarely needs albuterol during the day except when he has an upper respiratory tract viral infection. Based on this history, the most likely trigger for his nighttime asthma is: A. Allergic rhinitis C. Drop in endrogenous corticosteroid levels at night E. None of the above Ans: C A year-old girl has had asthma for 18 months.
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  • She typically complains of asthma symptoms 3 times per week on the average, with daily symptoms when she has a URIs. She complains of cough and shortness of breath with strenuous exercise. Her treatment to date has been an albuterol inhaler prn. At this point, the one clearly inadequate therapy for A. Start a leukotriene antagonist daily, albuterol inhaler prn and before exercise B. Start an inhaled corticosteroid at low to moderate dose, continue albuterol prn and before exercise C. Start the patient on a combined controller inhaler with inhaled steroid and long acting bronchodilator D. Start the patient on an inhaled steroid and leukotriene antagonist, and albuterol inhaler before exercise and prn E. All therapy strategies listed are adequate for this patient Ans: D A year-old male with known asthma for 27 years is seen in your office for a follow up of his asthma.
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  • He states his asthma has been in good control on his low dose of inhaled corticosteroid. But when asked about albuterol use, he says he uses it times daily. When asked about nighttime awakening due to asthma, he states he awakes because of asthma 3 times per month. He also tells you his asthma has been in good control and that he has not missed a day of work. You would characterize his asthma as: A. Mild intermittent.
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  • A Major difference between using anumal-derived antiserum vs. Antiserum has a longer half-life plasma. The antigen-specific Ig from hyperimmune globulin achieves a higher initial serum level. The second administration of antiserum is likely to have adverse reactions that the first. Hyperimmune globulin has a higher risk for serum sickness. All of the above are correct. Tight regulation of the immune system occurs via multiple mechanisms. Which is NOT one of these mechanisms? Permanent inactivation of self-reactive cells via clonal anergy. Suppression of self-reactive cells by T-cells C. Production of anti-idiotypic antibodies D. Release of inhibitory cytokines by lymphocites 3. Which of the following is a primary lymphoid organ? Spleen B. Bone Marrow C. Lymph Node D. Lung E. Gall Bladder 4. A batter for the Astros gets accidentally beaned by the pitcher and suffers left eye damage.
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  • Two weeks later, the right eye also becomes red and sore and vision is impaired. Which one of the following causes of autoimmunity is most likely? Failure of apoptosis to clear autoreactive T cells from the injured eye B. Molecular mimicry between the baseball and the eye D. Antigens released from the injured eye not before encountered by the immune system are now being targeted in the uninjured eye E. None of the above 5. The half-life of maternal IgG in a newborn is typically: A. Less than a week One to two weeks 1 month 2 to 6 months 1 year 1 6. The earliest response to the first exposure to a virus is A. They can kill by ADCC-mediated mechanisms They express antigen-specific receptors They are large granular lymphocytes They can kill tumor cells They can kill virus-infected targets Organisms avoid host immune responses through which of the following mechanisms A. Antigenic modulation Immune deviation Immunesuppression Masking All of the above A 20 year old woman develops a red rash over her nose and cheeks after brief sum exposure.
    Link: https://pubmed.ncbi.nlm.nih.gov/32304994/
  • A screening test indicates that she has an autoimmune disease. The first vaccine commonly given to infants in the U. In patients with thrombotic thrombocytopenic purpura cytotoxic antibodies immediate hemolytic anemia. This is an example of which type of hypersensitivity reaction? To determine the HLA haplotypes of the donor and recipient in preparation for a familial kidney transplant you need to examine: A. HLA of donor only B. HLA of recipient only C. HLA of donor and recipient D. HLA of multiple family members 3 They have some surface markers in common with T cells. Drainage of antigens into lymph nodes Processing of antigens for presentation to lymphocytes Delivery of mature lymphocytes to secondary lymphoid tissue Reduction in inflammatory exudates Circulation of helper and cytotoxic T lymphocytes Vasolidation B.
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  • Contraction of smooth muscle C. Direct lysis of target cells via MAC formation D. Chemoattractant for eosinphils E. Chemoattractant for neutrophils The immune response to lepromatous leprosy is skewed toward the production of which cytokines: A. IL-4 and IL C. IL-6 and IL D. IL-2 and IFN-gamma TO which major histocompatibility class does this allele belong? A child with congenital asplenia a genetic defect where the individual has no spleen would develop the best IgG antibody response using which route of immunization: A.
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  • Intravenouse Subcutaneous Oral Equal response to all the above A 20 year old woman becomes increasing hyperactive, loses weight despite an increase appetite, and her friends tell her that her eyes are becoming more prominent. Her physician diagnoses Graves disease. Which one of the following autoantibodies is the cause of her disease? Anti-nuclear Anti-thyroid stimulating hormone receptor Anti-acetylcholin receptor Anti-thyroglobulin Polymorphisms of which one of the following immune system genes have shown the strongest genetic associations with autoimmune diseases? Complement C4 alleles B. T cell receptor beta alleles C. Immunoglobulin light chain alleles D. None of the above. Deposition of antigen-antibody immune complexes in the glomeruli is most characteristic of which one of the following autoimmune diseases? Systemic lupus eythematosus Myasthenia gravis Type I diabetes mellitus Autoimmune hemolytic anemia None of the above.
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  • A 10 year old boy develops polyuria excessive quantities of urine and weight loss. His blood sugar is found to very high. Which one of the following autoimmune mechanisms is likely to be present? Cell-mediated destruction of pancreatic islet cells in the pancreas Autoanitibodies to circulating insulin Cell mediated destruction of thyroid Autoantibodies to liver glycogen None of the above 5 Which complement protein is most abundant in serum 1. C1 C2 C3 C4 C5 Antigen-antibody complexes comprised of which of the following immunoglobulins act as the most potent activators of the classical pathway of complement? A patient is admitted to your clinic with an autoimmune disease and is missing the second complement component C2.
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  • Which of the following would NOT be affected by this defect? Classical pathway Alternative pathway Lectin pathway Neither B or C would be affected All complement pathways would be affected. Gp is the principal viral receptor involved in the binding of HIV to host cells. Gp41 is involved in the internalization of HIV D. In latently infected cells, the viral genome persists for months to years as a double stranded, circular RNA molecules in the host cell nucleus. The virus produces its own reverse transcriptase, which has served as a target for anti-HIV drugs. Cytokines A. Are large, high molecular weight proteins Are produced only by lymphocytes and macrophages Are very stable and have long plasma half lives Each have distinctive biological activities that do not overlap with those of other cytokines.
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